Mark Ellisman/National Center for Microscopy and Imaging Research

Biologists have just created a new species of bacteria with just 437 genes

The simplest genetic life form ever.

DAVID NIELD
26 MAR 2016
 

A team of scientists led by renowned biologist Craig Venter has made a breakthrough some 20 years in the making: they've managed to create a species of bacteria in the lab with a genetic code that's smaller than any found in nature. With just 437 genes, the lab-made organism is carrying the absolute known minimum amount of genetic code required to support life.

By creating this self-replicating bacterium, scientists from the Synthetic Genomics lab and the J. Craig Venter Institute hope to get a better understanding of the function of the individual genes that make up every living organism - while we're making new discoveries all the time, there's still a lot we don't know about these vital biological building blocks.

 

Of the catchily named JCVI-syn3.0 microbe's 437 genes, only 149 have a known function. In other words, we know the rest are necessary for life to exist, but we haven't figured out what their purpose is yet. To help scientists find out more, what Venter and his team are now learning from this experiment is being added to a public database so anyone can study them.

"Our attempt to design and create a new species, while ultimately successful, revealed that 32 percent of the genes essential for life in this cell are of unknown function, and showed that many are highly conserved in numerous species," said Venter. "All the bioinformatics studies over the past 20 years have underestimated the number of essential genes by focusing only on the known world."

Just for comparison, while this organism has 437 genes, the shortest genome in a self-sustaining, living organism found in nature is 525 genes long, and belongs to Mycoplasma genitalium.

437-genesVenter et. al. Science

A trial-and-error chemical synthesis and genome design process was at the centre of the work done by the researchers, as they looked for a viable result.

Each test genome was built in eight segments at a time, with each one tested separately, before the organism was successfully made. The team and others in the field say the creation of synthetic life will eventually prove useful for specific purposes, such as producing cheap biofuel and creating new medicines from scratch.

In fact, there's a wealth of possibilities: Venter is friends with Elon Musk and has talked in the past about synthesising life to terraform the surface of Mars. "The goal of completely defining what it means to be considered alive has taken a giant step forward," Sir Richard Roberts, who won the 1993 Nobel Prize in biology and is now chief scientific officer of New England Biolabs, but who was not involved in this research, told Matthew Herper at Forbes.

The challenge now is to figure out the function of those mysterious 149 extra genes, and take the study of synthetic life further still - the researchers admit it might be possible to create a living organism with even fewer genes further down the line. "We view life as DNA software-driven," Venter said in a press statement. "And we're showing that by trying to understand that software, we're going to get better understandings of life."

His team's work has now been published in the journal Science.

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