J Yue, P Zhao, J Y Gerasimov et al/University of Groningen

These 3D-Printed Antimicrobial Teeth Could One Day Replace Fillings

Not as flash as gold, but a heck of a lot more hygienic.

PETER DOCKRILL
21 OCT 2015
 

Nobody likes going to the dentist. No matter how much effort you put into keeping your teeth clean, you could always be doing more – according to your dentist, at least. And they’re quite happy to threaten you with fillings (or worse) if they don’t get what they want.

 

But the current status quo of dental fillings and implants could face a significant overhaul in the coming years, thanks to the advent of 3D printing, and one new concept tooth in particular.

Researchers in the Netherlands have successfully created a 3D-printed tooth implant made from an antimicrobial resin that kills harmful bacteria in the mouth. In other words, this is a tooth that effectively cleans itself.

The plastic used in the tooth incorporates antimicrobial quaternary ammonium salts that are positively charged, which means they can eliminate negatively charged bacterial membranes.

“The material can kill bacteria on contact, but on the other hand it’s not harmful to human cells,” one of the researchers, Andreas Herrmann of the University of Groningen, told Jacob Aron at New Scientist.

The addition of alternative materials to a basic polymer is one of the current challenges in 3D printing, but the incorporation of active chemical substances such as the antimicrobial salts used here could be a huge boon for the medical industry, which could use sterile or antimicrobial 3D implants in a huge range of potential applications.

“[W]e have a prototype at hand that is suited for further testing in a clinical setting, including not only dental applications but also, for instance, orthopaedic ones like spacers and other polymeric parts used in total hip or knee arthroplasties,” the researchers write in their paper. “Moreover, the approach to developing 3D printable antimicrobial polymers can easily be transferred to other non-medical application areas, such as food packaging, water purification, or even toys for children.”

To test the efficacy of their antimicrobial plastic, the researchers coated samples of the resin in a mixture of the saliva and Streptococcus mutans bacteria – a significant contributor to tooth decay. The antimicrobial material killed 99 percent of the bacteria, whereas a sample of untreated resin resulted in 99 percent of the bacteria remaining.

“For clinical use we need to extend this [research], and investigate the compatibility with toothpaste,” said Herrmann, but the researchers are confident for the prospects of antimicrobial dental implants. “It’s a medical product with a foreseeable application in the near future, much less time than developing a new drug.”

The research is published in Advanced Functional Materials.

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