Nobody knows who she was, just that she was different: A teenage girl from over 50,000 years ago of such odd uniqueness she appeared to be a 'hybrid' ancestor to modern humans that scientists hadn't seen before.
Only recently, researchers have uncovered evidence she wasn't alone. In a 2019 study analyzing the tangled mess of humanity's prehistory, scientists used artificial intelligence (AI) to identify an unknown human ancestor species that modern humans encountered – and shared dalliances with – on the long trek out of Africa millennia ago.
"About 80,000 years ago, the so-called Out of Africa occurred, when part of the human population, which already consisted of modern humans, abandoned the African continent and migrated to other continents, giving rise to all the current populations," explained evolutionary biologist Jaume Bertranpetit from the Universitat Pompeu Fabra in Spain.
As modern humans forged this path into the landmass of Eurasia, they forged some other things too – breeding with ancient and extinct hominids from other species.
But in this study, a third ex from long ago was isolated in Eurasian DNA, thanks to deep learning algorithms sifting through a complex mass of ancient and modern human genetic code.
Using a statistical technique called Bayesian inference, the researchers found evidence of what they call a "third introgression" – a 'ghost' archaic population that modern humans interbred with during the African exodus.
"This population is either related to the Neanderthal-Denisova clade or diverged early from the Denisova lineage," the researchers wrote in their paper, meaning that it's possible this third population in humanity's sexual history was possibly a mix themselves of Neanderthals and Denisovans.
In a sense, from the vantage point of deep learning, it's a hypothetical corroboration of sorts of the teenage girl 'hybrid fossil' identified in 2018; although there's still more work to be done, and the research projects themselves aren't directly linked.
"Our theory coincides with the hybrid specimen discovered recently in Denisova, although as yet we cannot rule out other possibilities," one of the team, genomicist Mayukh Mondal from the University of Tartu in Estonia, said in a press statement at the time of discovery.
That being said, the discoveries being made in this area of science are coming thick and fast.
Also in 2018, another team of researchers identified evidence of what they called a "definite third interbreeding event" alongside Denisovans and Neanderthals, and a pair of papers published in early 2019 traced the timeline of how those extinct species intersected and interbred in clearer detail than ever before.
There's a lot more research to be done here yet. Applying this kind of AI analysis is a decidedly new technique in the field of human ancestry, and the known fossil evidence we're dealing with is amazingly scant.
But according to the research, what the team has found explains not only a long-forgotten process of introgression – it's a dalliance that, in its own way, informs part of who we are today.
"We thought we'd try to find these places of high divergence in the genome, see which are Neanderthal and which are Denisovan, and then see whether these explain the whole picture," Bertranpetit told Smithsonian.
"As it happens, if you subtract the Neanderthal and Denisovan parts, there is still something in the genome that is highly divergent."
The findings were published in Nature Communications.
A version of this article was originally published in February 2019.