In the wake of the US's latest mass shooting in Las Vegas - tragically the deadliest in the country's history - there is continued debate over whether or not more closely regulating the sale of firearms might prevent these types of events in future.

While it's an incredibly heated topic, last year, the largest study ever conducted on the topic found a clear link between firearm regulation and fewer gun-related deaths around the world. 

Before this, studies on gun laws were limited to just one city or country, and have failed to reach consistent conclusions. But the March 2016 research paper took a broader view - the team reviewed 130 high-quality studies conducted in 10 countries over the past 60 years.

And while they stopped short of saying they've conclusively proved that gun restrictions equal fewer deaths, the research provides pretty powerful evidence to suggest that it's the case.

"Across countries, instead of seeing an increase in the homicide rate, we saw a reduction," lead researcher Julian Santaella-Tenorio from Columbia University told Zack Beauchamp over at Vox at the time.

To figure this out, Santaella-Tenorio and his team systematically analysed 130 studies that had been conducted across 10 different countries, including the US, Australia, Brazil, South Africa, and Austria.

Each of the studies looked at some kind of specific gun legislation change, and its impact on gun-related homicides, suicides, and/or unintentional injuries or deaths, and was carefully selected for the quality of its research.

After analysing all of these studies, the researchers came up with three conclusions:

  1. It usually takes major legislation overhaul - not just one new law - to see significant change.
  2. Restricting access to guns and their purchase is associated with reductions in firearm deaths.
  3. Individual studies need to be better executed and planned in future to get more convincing results.

That first point is particularly interesting. Because the 130 studies were mostly dealing with different laws, the review wasn't able to pinpoint one specific 'magic' legislation that turned gun deaths around.

But it showed that when countries pass several laws at once that worked together to overhaul the country's firearm code, gun-related deaths tended to decrease.

Santaella-Tenorio told Beauchamp that these overhauls generally included:

  • Banning "weapons that are actually very powerful", for example, automatic weapons.
  • Implementing background checks.
  • "They all required permits and licenses for purchasing guns," Santaella-Tenorio told Vox.

For example, in South Africa in 2000, the Firearm Control Act contained all these measures, and saw a 13.6 percent reduction in firearm homicides every single year for the next five years. 

A similar overhaul law was introduced in Australia in 1996 in the wake of a mass murder, and according to one study, overall firearm death rates decreased by 14 percent the following year. Tellingly, there also hasn't been another mass shooting in the country in the 20 years since.

But even outside of those huge overhauls, small changes were found to make a difference.

"Laws restricting the purchase of (e.g. background checks) and access to (e.g. safer storage) firearms are also associated with lower rates of intimate partner homicides and firearm unintentional deaths in children, respectively," the researchers write in Epidemiologic Reviews.

On the opposite end of the scale, in 2007, Missouri got rid of laws requiring people to have a permit to purchase a firearm. Following this legislation change, one study found that Missouri's homicide rate increased by 25 percent. No other changes in legislation appear to be able to explain the change. 

Of course, there are limitations to the studies being analysed here. For starters, all of them were observational, which meant that researchers couldn't control for variables. That's a problem, because there are a whole lot of other factors in society that influence gun deaths outside of gun law, and by simply looking at the data after the fact, those patterns aren't always obvious.

A longitudinal study - where researchers are doing long-term monitoring of a population that just happens to have its gun laws changed halfway through - would be better, but that kind of happy coincidence is impossible to plan, and as yet hasn't happened by chance.

The authors of each of the 130 studies could have also had affiliations and personal interests that might have biased their results, Santaella-Tenorio and the team admit (who, for the record, declared no conflicts of interest in their review).

But they believe that their analysis provides compelling evidence that gun control really does save lives. And they hope that better research will point to some clear, evidence-based solutions for the United States.

"This information is key to move this field forward," the authors write, "and for the development of effective policies that may counteract the burden that firearm injuries pose on populations."

A version of this story was first published in March 2016.